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This entry or formulation may be investigational and may not correspond to an FDA-approved product; safety and efficacy may not have been established. Kairo lists it for identification and record-keeping only.
Overview
Product & regulatory status
Research compound; the cited study is not a human treatment trial.
Enzyme target
NNMT modifies nicotinamide. Researchers examined cell-permeable inhibitors to alter this metabolic process and measured effects in adipose cells and mice. [1]
What the evidence shows
Mouse obesity experiment
Researchers treated diet-induced obese mice for 11 days and reported lower body weight and fat measures than in controls. The small experiment used nine animals per group. [1]
Mechanistic finding versus clinical benefit
The study supports investigating NNMT inhibition in metabolic disease. It does not establish sustained weight loss, longevity, or a useful safety margin in people. [1]
What remains unknown
Human absorption, long-term effects, medication interactions, and clinically useful outcomes are not established by this animal paper.
Safety
Safety evidence gap
A short mouse experiment cannot reliably detect uncommon or delayed human adverse effects. The study should not be read as a declaration that 5-Amino-1MQ is safe for self-treatment. [1]
Research exposure
The obesity experiment used injected compound in mice. It does not establish the performance of capsules offered to consumers. [1]
Understanding product quality
Compounded drugs are not FDA-approved finished products. Poor preparation can cause contamination or incorrect strength. A catalog entry or a research paper is not a quality assessment of your product. [2]
When to seek urgent help
Severe allergic symptoms such as trouble breathing, throat or tongue swelling, or fainting need immediate help. Call 911 or your local emergency number. This is general emergency information, not a complete list of risks for this compound. [3]
A starting point for discussion
This is not a complete list of adverse effects or interactions. Your health history, other medicines, and the exact formulation matter. Missing safety data is not evidence of safety.
Common questions
Does NNMT inhibition mean it is an NAD+ supplement?
No. Inhibiting an enzyme and supplying a nutrient are different interventions, and neither label predicts a clinical outcome.
Questions for your clinician
Does the evidence match my condition and this exact product? What risks or interactions matter for me? How would we assess whether it is helping?
Sources
- Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice2017 · Primary research · PubMed
- Compounding and the FDA: Questions and AnswersFDA · product quality and regulation
- AnaphylaxisMedlinePlus · recognizing an emergency
Educational information, not a recommendation to use a compound. Kairo does not give dosing advice. Review decisions with a licensed healthcare professional.